AI-Based Therapies for Chronic Brain Disorders
Artificial intelligence is rapidly transforming the landscape of neurological research, and the Reddy Lab is at the forefront of applying these tools to the treatment of epilepsy and chronic brain disorders. Through an interdisciplinary approach bridging pharmacology, biomedical engineering, and machine learning, the lab is developing AI-driven smart therapies capable of predicting seizure onset and personalizing treatment
CBD and Epilepsy Prevention
Cannabidiol (CBD) has gained widespread public attention, but its clinical potential in epilepsy is grounded in rigorous science. Research from the Reddy Lab has been instrumental in uncovering the antiseizure and disease-modifying properties of CBD
From Mechanism to Disease: Translational Epilepsy Biology
Epilepsy and seizure disorders affect nearly 3 million people in the United States, including civilians and veterans, highlighting the need for improved therapies. The Reddy Lab focuses on developing novel, mechanism-based treatments for epilepsy and related brain disorders, addressing conditions such as catamenial and pediatric epilepsy, status epilepticus, post-traumatic epilepsy (PTE), and chemical and organophosphate neurotoxicity.
Military Medicine and Chemical Neurotoxicity
Exposure to chemical warfare nerve agents and organophosphate compounds poses severe and lasting neurological risks to both military personnel and civilians. The Reddy Lab has conducted extensive research into the mechanisms of chemical neurotoxicity, with the goal of developing effective medical countermeasures for those exposed to these life-threatening substances.
Neurosteroid Therapy for Epilepsy
Neurosteroids are naturally occurring compounds synthesized within the brain that play a critical role in regulating neural excitability. The Reddy Lab has spent decades conducting pioneering investigations into how these compounds interact with GABA-A receptors, the brain’s primary inhibitory signaling pathway.
Post-Traumatic Epilepsy
Post-traumatic epilepsy (PTE) is a devastating and often medically uncontrollable condition that develops in a significant portion of people following traumatic brain injury. Research from the Reddy Lab has focused on identifying the molecular and epigenetic mechanisms that drive its development, with particular attention to the critical window between injury and the onset of seizures
Postpartum Depression and Women’s Brain Health
Postpartum depression affects nearly one in eight women in the United States, yet effective, targeted treatments have historically been limited. The Reddy Lab has conducted pioneering research into the neurobiological mechanisms underlying postpartum depression.
Sleep and Sex Differences in Brain Injury
Traumatic brain injury does not affect all patients equally, and emerging research from the Reddy Lab has shed important light on two underexplored variables: sleep and biological sex.